Microdosing 101

Microdosing in Colorado: Fadiman vs. Stamets Protocols

Explore the Fadiman Protocol and Stamets Stack for microdosing in Colorado. Learn the benefits, dosage guidelines, and legal updates, and get started with our Free Guide and coaching membership

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Min read
Cori Sue Morris
January 1, 2025

Getting Started with Microdosing in Colorado: Fadiman vs. Stamets Protocols

Microdosing—the practice of consuming sub-perceptual doses of psychedelics—has gained significant traction in Colorado, especially following recent legislative changes. Two prominent microdosing protocols are the Fadiman Protocol and the Stamets Stack, each offering unique approaches to this practice.

Benefits of Microdosing in Colorado

Microdosing in Colorado provides a wide range of benefits that are increasingly supported by research. Studies have shown that microdosing can improve focus, productivity, and creativity, making it an attractive option for professionals and artists. It has also been linked to reduced symptoms of stress, anxiety, and depression, contributing to a greater sense of emotional balance and well-being.

Research published in Scientific Reports in 2019 found that 26.6% of microdosers reported improved mood, while 14.8% experienced increased focus. Additionally, a study from the same year revealed that individuals who microdosed with psilocybin or LSD over a six-week period experienced decreased levels of stress and depressive symptoms. Those who sought psychological support during their microdosing journeys reported even greater improvements in symptoms of PTSD, anxiety, and depression.

Microdosing has also been associated with better decision-making, heightened clarity of purpose, and an increased sense of optimism. It fosters self-awareness and encourages individuals to take greater responsibility for their actions and perspectives. This holistic approach to personal growth and mental well-being aligns with Colorado's progressive wellness movement, offering a supportive environment to safely explore the transformative potential of microdosing.

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How to Pick the Right Microdosing Protocol

Choosing the right microdosing protocol is a personal decision and should be tailored to your goals and lifestyle. Microdosing is an intuitive practice, unlike taking a prescription pill on a fixed schedule. The key is to find a flow and cadence that align with your daily routines and mental state. If you’re new to microdosing, the Fadiman Protocol is often the best starting point due to its simplicity and structured approach, allowing for gradual adjustment. On the other hand, the Stamets Stack may be better suited for those looking to optimize mental performance or enhance creativity, especially if following a traditional workweek. Take the time to explore what works for you and be open to adjusting your approach as needed.

Considerations Before Microdosing

Before embarking on a microdosing regimen, consider the following:

  • Legal Status: While Colorado has decriminalized certain psychedelics, they remain illegal under federal law.
  • Health Conditions: Consult with a healthcare professional, especially if you have underlying health issues or are taking other medications.
  • Accurate Dosing: Precise measurement is crucial to avoid unintended psychoactive effects.
  • Set and Setting: Ensure you're in a safe and comfortable environment when microdosing.

Questions to Ask Yourself Before Microdosing

Before starting a microdosing regimen, take time to reflect on your intentions and lifestyle to ensure the practice aligns with your goals. Consider these questions:

  • What are my intentions with microdosing?
    • Are you seeking mental clarity, emotional balance, enhanced creativity, or spiritual growth?
  • When do I wake up, and what does my morning routine look like?
    • Understanding your daily rhythm can help determine the best time to microdose.
  • Are my primary goals mental, physical, or spiritual?
    • Identifying your focus will guide you in selecting the most suitable protocol.
  • How can I create space for microdosing in my day-to-day life?
    • Building a mindful routine around your microdosing practice ensures it integrates seamlessly into your lifestyle.

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Overview of Dosage

A typical microdose is about 1/10th to 1/20th of a standard recreational dose. For psilocybin mushrooms, this equates to approximately 0.1 to 0.3 grams of dried material. It's advisable to start with the lower end of this range to assess individual sensitivity.

The Fadiman Protocol

Developed by psychologist James Fadiman, this protocol involves a three-day cycle:

  • Day 1: Microdosing day.
  • Day 2: Transition day (aftereffects may be felt).
  • Day 3: Normal day (no microdosing effects).

This cycle is repeated for several weeks, followed by a break to prevent tolerance buildup. The Fadiman Protocol is popular among beginners due to its structured approach and built-in rest days. (Learn more)

The Stamets Stack

Mycologist Paul Stamets introduced a protocol combining:

  • Psilocybin Mushrooms: For their psychoactive properties.
  • Lion's Mane Mushrooms: Believed to promote neurogenesis and enhance cognitive function.
  • Niacin (Vitamin B3): Intended to aid in the distribution of the other compounds throughout the nervous system.

The typical schedule involves microdosing for four consecutive days, followed by three days off. This combination, known as the "Stamets Stack," aims to synergistically enhance brain health and cognitive function. (Learn more)

Legislative Changes for Microdosing in Colorado

In November 2022, Colorado voters passed Proposition 122, known as the Natural Medicine Health Act, which decriminalized the personal use, possession, and cultivation of natural psychedelics, including psilocybin mushrooms, for individuals aged 21 and older. This landmark legislation marks a significant shift in the state's approach to psychedelics, fostering a supportive environment for practices like microdosing. While personal use is now decriminalized, commercial sales of psilocybin remain prohibited until a regulated framework is established. Licensed healing centers, where individuals can consume these substances under supervision, are expected to be operational by late 2024.

Community and Support for Microdosing in Colorado

Microdosing in Colorado is supported by a growing community of individuals interested in personal growth and mental well-being. If you’re new to this practice or want to deepen your understanding, our Free Guide provides the essential knowledge to safely and effectively integrate microdosing into your life.

For those ready to take their microdosing journey to the next level, our 1:1 Microdosing Coaching Membership is an excellent option. This three-month program connects you with experienced psychedelic medicine coaches who create personalized dosage plans aligned with your goals. With biweekly coaching sessions, ongoing support between meetings, and access to a private community, this membership provides a confidential, outcomes-driven approach to microdosing. Explore our Free Guide here and learn how our coaching membership can help you unlock the full benefits of microdosing.

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About the Author

Cori Sue Morris

Cori Sue is the founder & CEO of Retreat. She’s a recovering journalist and serial entrepreneur, having started, scaled and sold a media company, Bitches Who Brunch, and a marketing agency. She loves mushrooms, microdosing, empowered women, and helping others.

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